INS and polycystic ovary syndrome: Genetically determined body fat percentage (OR 3.05, 2.24–4.15), whole body fat mass (OR 2.53, 2.04–3.14), fasting serum insulin (OR 6.98, 2.02–24.13), and SHBG concentration (OR 0.74, 0.64–0.87) were all significantly associated with PCOS in a linear relation.