This has been shown with metformin therapy in low-birthweight girls, and with weight loss in adults/adolescents with PCOS and obesity, with reduced adiposity and insulin sensitizing addressing hyperandrogenism, insulin resistance and restoring normal ovulatory function (Gambineri et al., 2002; Kuchenbecker et al., 2011; Lass et al., 2011). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.