TP53 and cancer: The p53-MDM2 interactionis an important cancer target, where inhibitingthe interaction would allow p53 to remain free in the cell and triggerapoptosis.13 The p53 epitope is intrinsicallydisordered and adopts a helical conformation upon binding MDM2 andthe homologous MDMX14.10 MDM2 has a deephydrophobic cavity, where three hydrophobic residues (Phe1 9,Trp23,and Leu26) from the peptide anchor themselves, adopting a helicalconformation upon binding.