Tauopathies, including Alzheimer’s Disease (AD), Progressive Supranuclear Palsy (PSP), Pick’s Disease and Corticobasal Degeneration, are a group of neurodegenerative disorders characterized by the abnormal deposition of the microtubule-associated protein tau into filamentous neuronal inclusions. The gene discussed is MAPT; the disease is Classical progressive supranuclear palsy.