Here, we prepared PHFs from the Globus Pallidus of PSP donors, as this region is one of the earliest to be affected in the course of PSP [52, 53], and used them to induce the formation of tau-tau interactions in the Biosensor assay, as well as to promote the formation of AT8 and MC-1 positive Triton-insoluble tau inclusions in hTau mouse primary neurons. Here, MAPT is linked to supranuclear palsy, progressive, 1.