PMM2 and hyperinsulinemic hypoglycemia, familial, 4: AT-007 from Applied Therapeutics has received Orphan Drug and Pediatric Rare Disease designations from the FDA to treat SORD deficiency, Galactosemia, and phosphomannomutase-2 deficiency, a congenital disorder of glycosylation (PMM2-CDG) featured by increased sorbitol level (32).