The findings that Rbm47-IKO mice exhibit enhanced small intestinal proliferative capacity and spontaneous polyposis, coupled with findings from patients with colorectal cancer (CRC) showing an association between loss of RBM47 and tumor progression (29), led us to ask whether intestinal Rbm47 deletion might magnify the colonic tumor burden in a model of colitis-associated cancer. The gene discussed is RBM47; the disease is colitis.