APOA1 and rheumatoid arthritis: Antibodies against apolipoprotein A-1 (ApoA1), a central component of HDL, have been associated with elevated CVD risks among patients with rheumatoid arthritis.2,44 One recent study found higher levels of anti-HDL antibodies in patients with APS and prior arterial thrombosis.45 Future studies should assess the effect of various aPL species and isotypes on HDL function.