A total of 18 invadopodia-related proteins were identified as sEV surface components, including adhesion molecules that may interact with receptors on target GBM cells (ITGA1, ITGA3, ICAM1) and proteolytic proteins (BSG, MMP14) that may activate extracellular MMP-2 to promote ECM degradation (Fig. 3E). Here, MMP2 is linked to glioblastoma.