Interestingly, four invadopodia-related sEV surface proteins were exclusively identified in sEVs from high invadopodia activity GBM cell lines, and these are known to play important roles in proteolysis (MMP14; MT1-MMP), adhesion-related signalling cascades (ICAM1; intercellular adhesion molecule-1, and cytoskeletal regulation/cell motility (FSCN1; fascin, CTTN; cortactin). This evidence concerns the gene ICAM1 and glioblastoma.