Zymographic analysis of GBM cell conditioned media revealed that MMP-2 (in both inactive (latent) and active forms) was the main protease secreted by the GBM cell lines, consistent with its role in GBM invasion and progression [34] (Fig. 1D), and correlated with the differences in FITC-gelatin degradation observed for each GBM cell model. The gene discussed is MMP2; the disease is glioblastoma.