ITGA6 and cancer: Additionally, 244 sEV proteins common to sEVs from all three GBM cell lines were identified as surface proteins upon comparison with EV surfaceome recently reported by Rai et al. [43], including adhesion-related proteins (ITGA3, ITGA5, ITGA6, ITGAV, ITGB1, NPTN), cytoskeletal proteins (ACTR2, ACTR3, CFL1) and growth factors (e.g. EGF), known to be involved in cancer cell growth and invasion (Fig. 2E).