Further interrogation of these clusters revealed that GBM cell lines with high invadopodia matrix-degrading activity (LN229 and MU41) had a greater abundance of proteins involved in invadopodia maturation and proteolytic activity (including BSG, CLIP1, MMP14, MMP2, RAB5A) than the low invadopodia activity cell line, MU4 (Fig. 3B). The gene discussed is MMP14; the disease is glioblastoma.