Recent reports, showing an FTY720 induced up-regulation of neuronal brain-derived neurotrophic factor (BDNF) expression (Deogracias et al. 2012; Doi et al. 2013; Fukumoto et al. 2014) and rescue of synaptic NMDA receptors in Aβ-treated neurons (Joshi et al. 2017), indicate synapto-protective effects of fingolimod in different AD models in vitro. The gene discussed is BDNF; the disease is Alzheimer disease.