MAPT and Alzheimer disease: More specifically, the authors identified genetic variants in seven of the 35 genes in the SM pathway to be significantly associated with AD and its (bio)markers (Baloni et al. 2022), Supplementary Table 3), which covered the whole spectrum of Amyloid-β, Tau, Neurodegeneration, and Cognition (A–T–N–C) measures of AD (Jack et al. 2018).