CRC patients with high TIMP1 expression showed increased activity in all 7 steps of the seven-step Cancer-Immunity Cycle, while TIMP1 expression was mostly correlative with release of cancer cell antigens (Step 1; Pearson, r > 0.4 both in TCGA and GSE39582), trafficking of immune cells to tumors (Step 4; Pearson, r > 0.4 both in TCGA and GSE39582), and infiltration of immune cells into tumors (Step 5; Pearson, r > 0.4 both in TCGA and GSE39582) (Supplementary Figure 8A, 8B). This evidence concerns the gene TIMP1 and cancer.