The release of the nuclear LC3 pool during starvation is regulated by SIRT1-dependent deacetylation, with LC3 exiting the nucleus in complex with the diabetes- and obesity-regulated nuclear factor (DOR) in preparation for its incorporation into the nascent isolation membrane (Huang et al., 2015; Mauvezin et al., 2010). Here, SIRT1 is linked to diabetes mellitus.