Expression of several autophagy genes including ULK1, ATG7, ATG16L1, UVRAG, and TFEB was significantly reduced following LMX1B suppression, as was expression of the selective autophagy/mitophagy receptors NDP52 and OPTN, and the mitophagy regulator and early-onset PD gene, PINK1 (Fig. 1 B). Here, OPTN is linked to Parkinson disease.