AIF1 and central nervous system cancer: Therefore, the dysregulated AIF-1 expression has been strongly linked to a range of diseases, including cardiac allograft vasculopathy [9], rheumatoid arthritis [10], hemangioma [11], gastric cancer, glioma [12, 13], malignant breast tumor [14, 15], pancreatic carcinoma [16], and hepatocellular carcinoma [17].