SCN8A and Generalized non-motor (absence) seizure: Scn8a encodes the voltage-gated sodium channel, NaV1.6, and mice with reduced NaV1.6 expression have frequent and well-characterized absence seizures, due at least in part to specific hypofunction of inhibitory neurons in the thalamus (Makinson et al., 2017; Papale et al., 2009).