Next, we investigated whether 8PN‐mediated CDCP1 reduction can increase the sensitivity to EGFR TKI in EGFR TKI‐resistant lung cancer cells, including H1650 (EGFR exon 19 deletion and PTEN mutant) and H1975 (EGFR L858R) cells. This evidence concerns the gene CDCP1 and lung carcinoma.