Considering the trends of higher ratios of MSI‐H and CIN in LGR patients might be caused by more frequent MMR‐gene mutations in LGR patients, we further compared these features in patients with only MMR‐gene mutations and found that the trends of higher ratios of MSI‐H and CIN in LGR patients did not appear in patients with only MMR‐gene mutations (Fig. S3) but persist after removing patients with MMR genes (Fig. S4). This evidence concerns the gene MRC1 and cervical squamous intraepithelial neoplasia.