MSH2 and hyperinsulinemic hypoglycemia, familial, 4: Similar to most of the germline SNVs/InDels which have co‐occurrence with somatic mutations are MMR genes, germline LGRs in MSH2 gene also has co‐occurrence with somatic mutations, which indicates that germline MMR‐deficiency (either germline SNV/InDel or LGR in MMR genes) might lead to elevated somatic mutation hits (Fig. 3A,B).