ALB and Cirrhosis: Albumin is the most abundant and arguably most important plasma protein in the human body.5 As liver disease progresses to decompensated cirrhosis, quantitative, qualitative, and functional changes to albumin occur, and supplementation with human serum albumin (HSA), a colloid preparation, is beneficial.6,7 Throughout the present paper, serum albumin levels will be referred to as albumin and human serum albumin as a drug product will be referred to as HSA.