In addition to the regulation of CAMSAP3 localization at junctions, we observed that KO of CGNL1 also leads to altered organization of the PAN of microtubules in Eph4 cells, altered cyst morphogenesis of mCCD cells, a more random orientation of apico-basal microtubules and apico-basal repositioning of nuclei in mouse intestinal columnar epithelium. Here, CAMSAP3 is linked to cyst.