Bonneau et al. found that the high expression of CDH11 mediated the pro-metastatic activity of a particular subset of cancer-associated fibroblasts in early luminal breast cancer [20], from which we posit that the influence of CDH11 expression on the propensity for metastasis in OSCC patients might be relevant to cancer-associated fibroblasts. This evidence concerns the gene CDH11 and breast carcinoma.