In this study, we suggested that overexpression of TR1 in the PD model decreases the levels of BRCA2, CUL4, and γ-H2AX compared with that of Tg-A53T; therefore, TR1 can protect against the DNA damage as shown in the vivo and in vitro experiments in the PD model (Fig. 4). Here, TXNRD1 is linked to Parkinson disease.