In silico analyses for the four coding genes of NIPA1, NIPA2, CYFIP1, and TUBGCP5 in the 15q11.2 region suggested cardinal disease associations of NIPA1‐Spastic paraplegia 6, NIPA2‐PWS/AS, CYFIP1‐fragile X syndrome and autism, and TUBGCP5‐AS (Rafi & Butler, 2020). Here, CYFIP1 is linked to Autosomal dominant spastic paraplegia type 6.