Cochran’s Q showed evidence of between SNP heterogeneity (p < 0.05) in both the IVW and MR-Egger analyses for 16 of these 30 outcomes: Anxiety, asthma, obesity, body mass index, body fat percentage, hip circumference, waist circumference, C-reactive protein level, unspecified arthrosis, unspecified joint disorders, unspecified soft tissue disorders, shoulder lesions, low back pain, gonarthrosis, dorsalgia and allergic disease. Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.