Cochran’s Q showed evidence of between SNP heterogeneity (p < 0.05) in both the IVW and MR-Egger analyses for 16 of these 30 outcomes: Anxiety, asthma, obesity, body mass index, body fat percentage, hip circumference, waist circumference, C-reactive protein level, unspecified arthrosis, unspecified joint disorders, unspecified soft tissue disorders, shoulder lesions, low back pain, gonarthrosis, dorsalgia and allergic disease. The gene discussed is CRP; the disease is osteoarthritis.