CHEK2 and ovarian carcinoma: Using targeted sequencing, some researchers have identified the mutational spectra of genes associated with breast and/or ovarian cancer and reported pathogenic abnormalities in genes (CHEK2, ATM, NBN, RAD50, RAD51C, RAD51D, BRIP, etc.)involved in cell response to DNA damage, homologous recombination repair, cell cycle checkpoint, or apoptosis with hereditary ovarian cancer [11–13].