The results show that about one-third of these ovarian cancer cases from the Volga-Ural region can be explained by a truncating mutation in one of these genes, most notably BRCA1. Of note, the common truncating variant c.5266dupC accounted for about 1 in 7 ovarian cancer cases in our cohort, supporting its predominant role and proposed origin in Russia [16]. The gene discussed is BRCA1; the disease is ovarian cancer.