According to some study reports, BDNF works in the development of schizophrenia, Parkinson’s disease, and Alzheimer’s disease by binding with TrkB and then activating PI3K/AKT signaling pathway [24]; CREB plays a key role in the occurrence and development of schizophrenia, perhaps associated with the regulation of CREB on BDNF expression [25, 26] ; The phosphorylation of upstream PI3K and its effector AKT can stimulate CREB activation in neurons [27]. Here, BDNF is linked to Alzheimer disease.