In the present study, we first tested the serum levels of BDNF, PI3K, AKT, and CREB related to neurotrophy, synaptic transmission, and cellular signaling in drug-naïve patients with first-episode schizophrenia, and then analyzed their correlations with schizophrenic depressive emotion and impulsive behaviors using more objective data. This evidence concerns the gene AKT1 and schizophrenia.