Our study showed that the expression levels of BDNF, PI3K, AKT, and CREB were significantly correlated with S-UPPS-P score, indicating that BDNF, PI3K, AKT, and CREB not only participate in the development of schizophrenia, the expression level of the PI3K-AKT signaling pathway can also be used as a state indicator of schizophrenic patients. The gene discussed is CREB1; the disease is schizophrenia.