In this study, we describe the comprehensive immune metabolic parameters (adipokines, pancreatic hormones and incretins) and cytokines of children with acute and convalescent COVID-19 and found that acute COVID-19 children exhibit altered levels of adipokines, pancreatic hormones and incretins, which discriminates them from convalescent COVID-19 and control children. This evidence concerns the gene GCG and COVID-19.