SPTBN1 and cancer: Moreover, GO functional analysis based on GSEA demonstrated that downregulation of SPTBN1 could exert its pro-cancer effects via affecting normal epidermoid cell differentiation in KIRC; while, upregulation of SPTBN1 could also exert its pro-cancer effects by dysregulating normal immunity-related activities, and electrolyte homeostasis in UVM (revised_Figure 9).