However, in UVM, overexpression of SPTBN1 positively correlated with the upregulated levels of infiltrating stromal cells, including endothelial cells (R = 0.352, p = 1.69E-03) and cancer-associated fibroblast (R = 0.325, p = 3.94E-03), and infiltrating immune cells, including Treg cells (R = 0.387, P = 5.01E-04), Th2 cells (R = 0.358, p = 1.38E-03), monocytes (R = 0.234, p = 4.08E-02) and M2-macrophage (R = 0.338, p = 2.67E-03) after adjusting tumor purity (Fig. 5B). The gene discussed is SPTBN1; the disease is cancer.