Intriguingly, SPTBN1 overexpression in KIRC was negatively correlated with the invasion of pro-tumor immune cells; however, in UVM, the correlation was positive, implying SPTBN1 expression in KIRC and UVM may interact with immune infiltration in different manners and this finding could also help explain contradictory outcomes in cancer patients’ survival. Here, SPTBN1 is linked to neoplasm.