In present study, by using TIMER 2.0 web-based platform to explore the expression patterns of SPTBN1 across TCGA cancers at mRNA level, we revealed the consistent findings that SPTBN1, compared to expression level in nontumor adjacent tissues, was frequently down-expressed in tumor tissues in most types of cancers, including BRCA, BLCA, CESC, GBM, KICH, KIRC, KIRP, LUAD, LUSC, PCPG, PRAD, THCA and UCEC. The gene discussed is SPTBN1; the disease is cancer.