For DSS, SPTBN1 acted as a detrimental role in patients with ACC (HR = 1.94, 95%CI, 1.11–3.38, p = 0.02), CESC (HR = 1.73, 95%CI, 1.12–2.68, p = 0.014), LUSC (HR = 1.37, 95%CI, 1.08–1.74, p = 0.01) and UVM (HR = 1.88, 95%CI, 1.11–3.20, p = 0.019), and a protective role in patients with KIRC (HR = 0.47, 95%CI, 0.38–0.58, p = 3.83E-13) and THYM (HR = 0.09, 95%CI, 0.01–0.75, p = 0.026). The gene discussed is SPTBN1; the disease is adrenal cortex carcinoma.