As shown in Fig. 2A, the mRNA expression levels of SPTBN1 in the cancer tissues of BLCA, BRCA, GBM, KICH, KIRC, LUAD, LUSC, PRAD, THCA, UCEC (all p < 0.001), PCPG (p < 0.01), and CESC (p < 0.05) were lower than the corresponding adjacent normal tissues, however, SPTBN1 mRNA expression in the tumor tissues of CHOL, LIHC, STAD (all p < 0.001), and HNSC (p < 0.05) were higher than their respective adjacent non-tumor tissues. The gene discussed is SPTBN1; the disease is cancer.