Specifically, by using TIMER 2.0 online platform, we further found that the SPTBN1 expression had a significant positive association with the infiltration of stromal cells, including endothelial cells (R = 0.625, p = 2.35E-51) and cancer-associated fibroblast (R = 0.131, p = 4.78E-03), and a obvious negative association with the infiltration of TIICs, including Treg cells (R =-0.305, p = 2.31E-11), Th2 cells (R =-0.316, p = 3.54E-12), monocytes (R =-0.177, p = 1.32E-04) and M2-macrophage (R =-0.251, p = 4.82E-08) in KIRC after adjusting tumor purity (Fig. 5A). Here, SPTBN1 is linked to cancer.