Moreover, based on TIMER 2.0 online platform, we also found that with the tumor progression, the expression of SPTBN1 was gradually decreased in KIRC cases; meantime, in UVM patients, the expression level of SPTBN1 was gradually increased (Fig. 1), implying that SPTBN1 expression is closely related to tumor types and stages/grades, and it should be noted that the role of SPTBN1 in cancer development may vary depends on different contexts. The gene discussed is SPTBN1; the disease is cancer.