For PFI, SPTBN1 played a protective role in cases with KIRC (HR = 0.61, 95%CI, 0.51–0.73, p = 8.19E-08), and a detrimental role in cases with ACC (HR = 2.74, 95%CI, 1.64–4.58, p = 0.0001), CESC (HR = 1.94, 95%CI, 1.33–2.85, p = 0.0006), PAAD (HR = 1.44, 95%CI, 1.06–1.97, p = 0.0209) and UVM (HR = 1.81, 95%CI, 1.16–2.85, p = 0.0095). Here, SPTBN1 is linked to adrenal cortex carcinoma.