For instance, decreased SPTBN1 expression could promote tumorigenesis and malignant manners, and act as a poor prognosis factor in some human cancers, like hepatocellular carcinoma[26] or high grade of pancreatic cancer[27]; however, increased expression of SPTBN1 could also promote carcinogenesis and predict poor prognosis in some cancers, such as ovarian cancer[28] and stage IV of colon cancer[29]. This evidence concerns the gene SPTBN1 and familial pancreatic carcinoma.