After analyzing of the skin cancer patient data from the TCGA database using the UCSC Xena web-based tool, a higher expression of Talin-1 was observed in skin cancer patients with metastases (n = 366) compared to primary tumor tissues (n = 102) (Welch’s t-test, p = 0.008 (t = -2.679)). The gene discussed is TLN1; the disease is neoplasm.