Given that the excessive activation of CD4+ T cells is an essential mechanism during SLE pathogenesis (Moulton and Tsokos 2015; Mak and Kow 2014), naïve CD4+ T cells were isolated from HCs and were induced activation in vitro to evaluate the possible involvement of m6A in CD4+ T-cell behavior. The gene discussed is CD4; the disease is systemic lupus erythematosus.