Moreover, METTL3 expression in SLE CD4+ T cells was indistinguishable between the DMSO and STM2457-treated groups (Additional file 6: Fig. S4f), indicating that STM2457 particularly inhibits the activity of METTL3 without apparently affecting its expression during Treg cell differentiation. The gene discussed is CD4; the disease is systemic lupus erythematosus.