Examples include REST as target for miR-9 (Packer et al. 2008), RCOR1, RGS2, HDAC4 as targets for miR-22 (Jovicic et al. 2013), MFN2 as target for miR-214 (Bucha et al. 2015) and miR-34a-5p as modulator of the p53/SIRT1-pathway in HD (Reynolds et al. 2018). The gene discussed is MFN2; the disease is Huntington disease.