Zinc finger proteins (ZFPs) primarily function as transcription factors in tumorigenesis and tumor progression involved in various tumor, such as esophageal squamous cell carcinoma cells [20],lung cancer [21], hepatocellular carcinoma [7], kidney renal clear cell carcinoma [22], oral squamous cell carcinoma [23]. The gene discussed is ZNF146; the disease is esophageal squamous cell carcinoma.