Notably, 3‐HAA treatment significantly upregulated the expression levels of Ly6C in macrophage and downregulated the expression level of chemotactic CCL2 produced by macrophages in HCC tissues, suggesting that 3‐HAA may inhibit HCC progression by remodeling the immunophenotyping of macrophage by inhibiting the CCL2/CCR2 pathway. Here, CCL2 is linked to hepatocellular carcinoma.