ACE and Hypertension resistant to conventional therapy: Resistant hypertension (RHTN) is defined as BP which is uncontrolled with ≥3 medications—commonly a long‐acting calcium channel blocker (CCB), a blocker of the renin‐angiotensin system [angiotensin‐converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB)], and a diuretic, all prescribed at maximal or maximally tolerated doses and at the appropriate dosing frequency.1