MAPT and early-onset autosomal dominant Alzheimer disease: Areas yielding the largest effect sizes in dysexecutive patients either compared with the HCP-A normative cohort or amnestic patients were mainly situated in the canonical parieto-frontal network, which is the macro-scale underpinning of executive functions.53,54,69,70 Areas typically associated with episodic memory capacities and known to be early sites of tau accumulation in amnestic Alzheimer’s disease, namely the hippocampus, parahippocampus and entorhinal cortex,71-74 showed selective neurodegeneration in amnestic patients.