MAPT and tauopathy: 44 Furthermore, NMNAT isoforms reportedly act as chaperones for proteostasis of tau in rodent models and have been shown to promote clearance of tau oligomers and suppression of tau-induced degeneration in Drosophila models of tauopathy.44‐46 As tau aggregation has been causally linked to tau-mediated toxicity in many experimental models of tauopathy,69 including Drosophila,67 it is conceivable that a reduction in misfolded tau may be suggestive of reduced tau aggregation and thus reduced tau toxicity in axons that have WldS pathway activation.