In this study, we genotyped the FSHR c.2039A>G (rs6166) polymorphism and one of the most common SNP in ESR1, ESR1 Pvull c.453-397 T > C (rs2234693), in a group of women with PCOS and a control group undergoing in vitro fertilization (IVF) treatments. This evidence concerns the gene FSHR and polycystic ovary syndrome.