ESR1 and polycystic ovary syndrome: Our first question was whether FSHR rs6166 and ESR1 rs2234693 were associated with PCOS risk. We did not find statistically significant differences in the distribution of each of the genotypes of FSHR rs6166 and ESR1 rs2234693 polymorphisms, suggesting that in our population, neither of the studied polymorphisms is associated with PCOS risk.