In this study, we genotyped the FSHR c.2039A>G (rs6166) polymorphism and one of the most common SNP in ESR1, ESR1 Pvull c.453-397 T > C (rs2234693), in a group of women with PCOS and a control group undergoing in vitro fertilization (IVF) treatments. The gene discussed is ESR1; the disease is polycystic ovary syndrome.