Though EVs from specific cellular populations were not isolated, the reduction of the oligodendrocyte marker MOG and the synaptic marker SNAP-25 in EVs from the ALS mice likely reflects the process of neurodegeneration and suggests that these proteins are promising markers for early signs of ALS and possibly other types of neurodegenerative diseases [156]. This evidence concerns the gene SNAP25 and amyotrophic lateral sclerosis.