To define the transcriptional profiles of the major subsets of MTC, naïve, TCM, and TEM cells from CD8+ and CD4+ lineages were FACS separated from the blood of four human donors using CCR7 and CD45RA as distinguishing cell surface markers (Fig. 1a, b, and Supplemental Fig. 1a). Here, CCR7 is linked to medullary thyroid gland carcinoma.