CDKN1B and intrahepatic cholangiocarcinoma: Similarly, Huang et al. [38] reported that YTHDF2 was upregulated in intrahepatic cholangiocarcinoma, and its knockdown resulted in the suppressed proliferation and G0/G1 cell cycle arrest by promoting CDKN1B (p27) degradation, further validating the role of YTHDF2 in cell cycle regulation.