To this end, we constructed a quadruple human gene knock-in (KI) Balb/c mice: PD1, PDL-1, CD47 and SIRPα (HuGEMM-PD1xPDL-1xCD47xSIRPα), similar to those used by others44 and a human CD47-KI mouse syngeneic A20 B-cell lymphoma, as schematic described in Supplement Fig. S2. Here, SIRPA is linked to B-cell non-Hodgkin lymphoma.