TARDBP and amyotrophic lateral sclerosis: Our results reveal elevation of the oxidative stress-responsive gene Homx1 in the cortex of rNLS8 mice from the 2-week time point, in line with evidence from the motor cortex of ALS or FTD-linked mutant TDP-43 transgenic mice [6, 63, 64] and in the lumbar spinal cord of SOD1G93A mice for ALS [65].