Moreover, we speculate that significant neuron loss occurs in the motor cortex of rNLS8 mice by 6 weeks off Dox, which may partly account for the late decrease of Bcl2, Bim, and Noxa expression in rNLS8 mice, consistent with previous findings that show decreases of Bcl2 mRNA in postmortem tissues in ALS and other human neurodegenerative diseases [35]. The gene discussed is PMAIP1; the disease is amyotrophic lateral sclerosis.