IGFBP2 and hemophilia A: These included a rearrangement in Xq24 associated with SHAM (severe hemophilia A and Moyamoya) syndrome [17] (ID76728), the recurrent 16p11.2 deletion [27] together with a 2.1 Mb copy number gain (4 copies) in 1q21.1-21.2 [28] (ID73732) as well as the recurrent 15q11.2 BP1-BP2 duplication [29] (ID69946).