In order to better model CC, we assessed NAD+ content in the skeletal muscle of Villin-Cre/Msh2loxP/loxP (VCM) mice that slowly and spontaneously develop neoplasms due to the conditional knock-out of the mismatch repair gene Msh2 in the enterocytes of the intestinal mucosa16. Here, MSH2 is linked to neoplasm.