PDGFB and central nervous system cancer: To determine whether MCPs have direct impact on tumor cells, we generated PDGFB-driven GBM in WT;Ntv-a mice and derived primary tumor cell cultures and maintained them in stem cell enriching medium— where we refer to them as WT primary glioma stem cell cultures (WT-GSCs) (Supplementary Fig. 8A), since we have previously shown that in these condition tumor cells retain better original tumor cell properties and exhibit stem cell properties43–45.