Using PDGFB-driven GBM in Cx3Cr1GFP/WT;Ccr2RFP/WT mice, we previously demonstrated that CX3CR1LoCCR2Hi monocytes infiltrate GBM and transition to CX3CR1HiCCR2Lo/neg MDM and together constitute nearly 85% of the tumor-associated macrophages; while CX3CR1HiCCR2neg Mg only account for 15% of the myeloid cells and occupy mostly peritumoral areas30,46. The gene discussed is PDGFB; the disease is neoplasm.