In contrast to PDGFB- and EGFRvIII-driven murine GBM, and even more so than Nf1-silenced GBM, the major immune infiltrates in a genetic HCC mouse model are neutrophils similar what we saw with monocytes in PDGFB-driven GBM model. The gene discussed is PDGFB; the disease is hepatocellular carcinoma.