By creating a combined all MCP-deficient mouse (qMCP−/−) and generating orthotopic transplant model by injecting PDGFB-driven glioma cells into qMCP and wild-type (WT) mice we show that loss of expression of all MCPs in the TME results in a decrease of monocyte recruitment and extends survival of tumor-bearing mice. The gene discussed is PDGFB; the disease is central nervous system cancer.