Inspiringly, the M1-derived exosomes transfected with miR-511-3p, NF-κB p50 siRNA, and modified with IL4RPep-1 (binding to IL4R of TAMs) on the surface efficiently inhibit tumor growth by downregulating target genes, decreasing the levels of M2 cytokines and immune-suppressive cells, while increasing the levels of M1 cytokines and immune-stimulatory cells, thus repolarizing TAMs into anti-tumor M1 phenotype [173]. Here, NFKB1 is linked to neoplasm.