Exosomes rich in miR-33 and miR-130 increased the expression of M1 signature genes (IRF5, MCP1, CD80) and secretion of cytokines (IL-1β and TNF-α) as well as yeast phagocytic activity of macrophages, cheerfully decrease tumor progression by shifting M2 macrophages to M1 macrophages, providing us with a potential alternative for tumors [192]. This evidence concerns the gene CCL2 and neoplasm.