PDCD1 and neoplasm: Various approaches can achieve it, blocking different surface molecules involved in the immunosuppressive profile of TAMs like PD1-PDL1, CD206, CD63, CD204, SIGLEC1, MARCO, TREM2, etc. Inhibiting the “do not eat me” signaling to promote phagocytosis or disturbing the epigenetic activities of pro-tumor TAMs such as prostaglandin (PGE2) signaling, PI3k-γ signaling, or modulating the histone deacetylases, etc [190].