IRF4 and schistosomiasis: These cellular changes were accompanied by a significant reduction in Th2 cytokines IL-4 and IL-5 in Cre+ MGL2+ CD11b+ cDC2 depleted mice, as a proportion of CD4+ T cells (Fig. 6C), implicating Irf4-dependent dependent cDC2s as critical in promoting type-2 responses during pre-patent schistosomiasis.