Inhibition of cyclin-dependent kinase 7, a transcriptional kinase–mediated transcriptional initiation in trans-acting SE complex, constricted the transcription of inflammatory cascades, and extracellular matrix remodeling–related genes such as IL1β and MMP3 in NP cells, meanwhile, also restrained the transcription of Mmp16, Tnfrsf21, and Il11ra1 to retard IDD in rats. The gene discussed is CDK7; the disease is intervertebral disk degenerative disorder.