TNF-ɑ and IL1β are known to be the main pro-inflammatory cytokines involved in the pathophysiology of IDD (Le Maitre et al, 2007), and external stimuli such as abnormal stress can promote the expression of IL1β and TNF-ɑ in NP tissues (Lyu et al, 2021). This evidence concerns the gene TNF and intervertebral disk degenerative disorder.