Notably, while RNF167is highly expressed in almost all cancers, other ligases like RNF128(thyroid, liver, urothelial, and colorectal), RNF130 (gliomas), orRNF43 (colorectal cancers) show a more selective tissue-associatedexpression pattern (Figure 5A) in cancer cells. The gene discussed is RNF130; the disease is cancer.