Therefore, this study selected a high-performance single-atom Ce-N4-C-(OH)2 (SACe-N4-C-(OH)2) nanozyme with tandem superoxide dismutase (SOD)-, OXD-, catalase (CAT)-, and POD-like activities in liver and muscle glucose-metabolizing tissues to overcome substrate limitations and self-sufficiently produce •OH, thus having a good therapeutic effect in alleviating hyperglycemia. The gene discussed is CAT; the disease is Hyperglycemia.