We compared the KPP model to models harboring the constitutively active PDGFRAD842V mutation, as this mutation and another similarly constitutively active PDGFRA mutation (PDGFRAV544ins) have been utilized in recently published models of H3K27M and H3.3G34R gliomas (21, 38, 48, 52). The gene discussed is PDGFRA; the disease is glioma.