NRP2 and X-linked intellectual disability: In particular ZDHHC15, shown here to play essential roles in Nrp2 palmitoylation and function, has been implicated in X-linked intellectual disability (Lewis et al., 2021; Mansouri et al., 2005), impairments in learning and memory (Wang et al., 2015), hyperactivity associated with a novel environment and sensitivity to psychostimulants (Mejias et al., 2021), and also dendritic outgrowth and formation of mature spines in hippocampal neurons in vitro (Shah et al., 2019).