In particular ZDHHC15, shown here to play essential roles in Nrp2 palmitoylation and function, has been implicated in X-linked intellectual disability (Lewis et al., 2021; Mansouri et al., 2005), impairments in learning and memory (Wang et al., 2015), hyperactivity associated with a novel environment and sensitivity to psychostimulants (Mejias et al., 2021), and also dendritic outgrowth and formation of mature spines in hippocampal neurons in vitro (Shah et al., 2019). Here, ZDHHC15 is linked to X-linked intellectual disability.