Potent C1 domain-binding PKC activators, such as phorbolesters,induce overstimulation and consequent downregulation of the enzyme.45 Antal et al.46 suggestedthat the phorbol ester-induced downregulation and consequent lossof function of PKC correlate to the tumor-promoting effects of thecompound. Here, PRRT2 is linked to neoplasm.