According to the above-mentioned results obtained from the current study, it is suggested that diosmin nanocrystal gel formulations can be a promising treatment for psoriatic lesions due to its ability to halt the immunopathogenesis of psoriasis, via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu and Tregs/Th17 balance. This evidence concerns the gene AKT1 and psoriasis.