Then use the prepared diosmin nanocrystals gel topically in 3 different concentrations to evaluate its efficacy in alleviating IMQ induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu and Tregs/Th17 balance. The gene discussed is RPS6KB1; the disease is psoriasis.