To reveal the role of immune pathways in psoriasis progression and treatment mechanisms, western blot analysis is performed to assess the protein expression of TLR-7/8/ P-NF-kβ p65, P-AKT/P-m-TOR/P70S6k, TNFAIP3, PCNA, and BCL-2, Fig. 10A, B. The TLR-7/8, P-NF-kβ p65, P-AKT, P-mTOR, and P70S6k expression were significantly elevated in the IMQ group highlighting their role in the disease immune pathogenesis. The gene discussed is PCNA; the disease is psoriasis.