Additionally, it was shown that TNF-α induced protein 3, encoding A20 (TNFAIP3/A20), which is a known inhibitor of NF-κB, was mitigated in the epidermis of psoriatic patients as well as its deletion in keratinocytes caused massive elevation in the expression level of inflammatory cytokines in psoriasis (Devos et al. 2019). The gene discussed is NFKB1; the disease is psoriasis.